193. The GLP-1 Revolution: Food Noise, Muscle Loss & The Future of Metabolic Medicine | Priya Jaisinghani. MD
Today, Dr. Priya Jaisinghani joins us to cut through the headlines. We move beyond the "cheating" narrative and explore the biology of obesity as a chronic disease. We discuss the phenomenon of "Food Noise"—the constant mental static about eating—and why silencing it is a matter of brain chemistry, not willpower.
We get into the weeds of patient selection, explaining why BMI is a broken metric (especially for South Asian populations) and why being "skinny" doesn't mean you’re metabolically healthy. We also tackle the serious risks: the "muscle crisis" (sarcopenia), the dangers of unregulated compounding pharmacies, and what happens when you stop these drugs.
What We Discuss:
The "Food Noise" Phenomenon
Patient Selection & The Broken BMI
The Muscle Crisis: Quality vs. Quantity
Safety, Side Effects & The Compounding Trap
The Future of Metabolic Medicine
Resources & Links:
Connect with Dr. Jaisinghani:
NYU Langone Profile: Dr. Priya Jaisinghani
Instagram: @DrJ_NYU
LinkedIn: Priya Jaisinghani, MD
Studies & Literature Mentioned:
SURPASS-3 MRI Sub-study: Reduction in Liver Fat and Muscle Fat with Tirzepatide
SELECT Trial: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (The "MACE" reduction data)
FLOW Trial: Semaglutide in Patients with Type 2 Diabetes and Chronic Kidney Disease
GRAMS Trial (Upcoming): GLP-1s and Musculoskeletal Outcomes
Medscape Article: Do GLP-1s Have Deleterious Effects on Muscle?
Podcasts & Videos Mentioned:
TEDx Talk: Dr. Melanie Jay: Weight Bias in Medicine
Concepts & People:
Dr. Gabrielle Lyon: Muscle-Centric Medicine
Dr. Spencer Nadolski: Lipidologist & Obesity Physician
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Guest Bio:
Dr. Priya Jaisinghani is a triple-board certified physician in Internal Medicine, Endocrinology, and Obesity Medicine, and currently serves as a Clinical Assistant Professor at NYU Grossman School of Medicine.
She completed her training at Weill Cornell and New York-Presbyterian Hospital before becoming a key architect at NYU Langone, where she helped build their official obesity clinical care pathway.
Dr. Jaisinghani is a leading voice in the cardiometabolic space, specializing in the intersection of hormonal health and metabolic dysfunction. She is deeply passionate about treating obesity as a chronic, complex disease rather than a willpower failure.
Beyond her clinical practice, she is a dedicated educator who has secured grant funding to develop tools that teach residents how to dismantle weight bias in the exam room. She serves as a vital bridge between endocrinology, bariatric surgery, and sports medicine to treat the whole patient.
